Invited Speakers

Luca Magnani

Luca Magnani

Luciano de Croce

Luciano de Croce

Toni Cathomen

Toni Cathomen

Jonathan Chubb

Jonathan Chubb

Geneviève Almouzni

Geneviève Almouzni

Christoph Plass

Christoph Plass

Lodewyk Wessels

Lodewyk Wessels

We have invited a core of 20 mainly established investigators and speakers with demonstrated excellent speaker capacities providing an attractive advertisement for our conference. We have carefully selected these invited/keynote speakers to cover the full spectrum of relevant topics in the field taking speaker’s gender into account.

The following speakers have accepted to speak at the meeting:

Keynote speakers:

  • Geneviève Almouzni, Institut Curie, FR
  • Jonathan Chubb, University College London, MRC, GB
  • Martin Fussenegger, ETH Zürich, CH
  • Pamela Munster, University of California, San Francisco, US

 Invited speakers:

  • Lucia Altucci, Institute of Genetics and Biophysics, IT
  • Pilar Blancafort, University of Western Australia, AU
  • Tiziana Bonaldi, European Institute of Oncology, SRSI, IT
  • Maria Carmo-Fonseca, Instituto de Medicina Molecular Lisbon, PT
  • Toni Cathomen, University Medical Center Freiburg, DE
  • Luciano Di Croce, Centre for Genomic Regulation, ES
  • Wouter de Laat, Hubrecht Institute, NL
  • Massimo Loda, Harvard Cancer Center, US
  • Jeantine Lunshof, MIT Media Lab, US
  • Luca Magnani, Imperial College London, GB
  • Christoph Plass, German Cancer Research Center, DE
  • Maria Rodriguez Martinez, IBM Research, CH
  • Paola Scaffidi, Francis Crick institute London, GB
  • Vahid Shahrezaei, Imperial College London, GB
  • Henk Stunnenberg, Radboud University Nijmegen, NL
  • Lodewyk Wessels, Netherlands Cancer Institute, NL

Geneviève Almouzni

Structure and function of dynamic chromatin organization

Prof. Geneviève Almouzni is Director of the Cancer Research Center Institut Curie, Paris (FR). She is head of the Nuclear Dynamics and Genome plasticity unit and group leader of the chromatin dynamics team. She obtained her PhD at Pierre-et-Marie-Curie University (FR), worked as postdoctoral fellow at the National Institutes of Health Research Center in Bethesda (USA) in the lab of Prof. Alan Wolffe. She has been CNRS Research Director since January 2000. In 2013, she was awarded the FEBS | EMBO Women in Science Award. She was scientific coordinator of the EU Network of Excellence EpiGeneSys.


Jonathan Chubb

 

Implications of transcriptional mechanism for cell decision-making

Prof. Jonathan Chubb is a Welcome Senior Fellow at the MRC Laboratory for Molecular Cell Biology, University College London. His group would like to understand how cells make choices about their fates.  To achieve this, they take the view that one needs to observe the gene expression of individual cells before and during the decision-making process, to test how initial cell "state" maps onto final cell fate.  In particular, his group develop and use approaches to image the transcription of genes in living cells.


Luciano di Croce

 

Molecular mechanisms governing cell differentiation and cancer processes

Since its formation, Di Croce’s group has focused its research efforts on understanding how epigenetic modifications and chromatin changes are established and, once in place, how they affect gene expression, cell differentiation and transformation.

Polycomb and MLL/Trithorax complexes are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recent data indicate that they regulate a plethora of cellular processes, including X chromosome inactivation, genomic imprinting, cell cycle control, stem cell biology, and cancer. Polycomb proteins form at least two distinct complexes: the Polycomb-repressive complexes 1 and 2 (PRC1 and PRC2), both possessing histone-modifying enzymatic activities resulting in monoubiquitination at lysine 119 of histone H2A and methylation at lysine 27 of histone H3, respectively. The catalytic activity and the binding of Polycomb to its genomic sites can be modulated by associated factors. The antagonistic function is performed by MLL complexes that trough deposition of methyl marks on lysine 4 of histone H3 positively regulate transcription, thus counteracting the activity of Polycomb complexes. I will discuss how Polycomb and MLL proteins (including novel associated factors) impact on transcription, genome architecture, and their role in stem cell biology.


Lucia Altucci

 

 

Università della Campania Luigi Vanvitelli, Dept. Biochimica Biofisica e Patologia Generale, MD, PhD; Specialisation in medical Oncology Full Professor of General Pathology &Rector’s delegate for Research & Innovation University of Campania Luigi Vanvitelli, Naples, IT.


Christoph Plass

 

 

 

 


Luca Magnani

 

 

Luca Magnani has trained in Italy and the US before starting his laboratory at Imperial College London. His background is in epigenetics. He has a strong interest in translational science, with a strong focus and breast cancer. He is currently supported by a CRUK career development fellowship and EU grants. His laboratory studies how tumors evolve in response to therapy using genomics and epigenomics. His multi-disciplinary team consist of a medics, biologists and computational biologists and uses and develops cutting-edge approaches to study breast cancer evolution.


Toni Cathomen 

Molecular mechanisms governing cell differentiation and cancer processes

Toni Cathomen is Professor of Cell and Gene Therapy and Director of the Institute for Transfusion Medicine and Gene Therapy at the Medical Center of the University of Freiburg, Germany. His research activities focus on the development of disease models and cell therapies based on induced pluripotent stem cells (iPSCs), the improvement of the effectiveness and safety of designer nucleases (CRISPR-Cas and TALEN) for targeted genome editing in clinically relevant human cells, and the development of immune cell therapies (CAR-T cells) for the treatment of various types of tumors.

 


 

 

L.F.A. Wessels

Integrative modeling for precision medicine

Lodewyk Wessels is the head of the Computational Cancer Biology group at the Netherlands Cancer Institute. His group focuses on quantifying and understanding treatment response in model systems and patients. To end they develop besproke and novel computational methods focusing on data integration and tailored to new technologies. Lodewyk Wessels holds a chair in Computational Cancer Biology at the Delft University of Technology and serves as Deputy Director Research of the Nehters Cancer Institute.